IR spectroscopy has long been used to study cells and living tissues, and now the analytical capabilities of synchrotron IR spectromicroscopy has expanded this ability. In their article, Hoi-Ying N. Holman, Hans A. Bechtel, Zhao Hao, and Michael C. Martin outline how this modern technology can meet the demands of modern biological research for studying molecular reactions in individual living cells. The cover, created by Robert Gates, shows an IR beam emitted from a synchrotron toward individual living cells (background) and IR spectra and molecular analytes in the foreground.